Prognostic factors in uterine carcinosarcoma

Uterine Carcinosarcoma after Pelvic Radiotherapy

Radiation is a treatment of many gynecologic malignancies, especially locally-advanced cervical cancer. Development of second malignancies is a rare complication of radiotherapy. Our patient had uterine carsinosarcoma20 years after radiotherapy for cervical cancer. Two theories of radiationinduced malignancies were described: direct damage of double strand DNA and the abscopal or indirect damag...

Uterine sarcoma: prognostic factors and treatment evaluation.

BACKGROUND Uterine sarcoma constitutes a highly malignant group of uterine tumors. It accounts for 2-6% of uterine malignancies and its incidence is 1.7 in 100,000 women. The three most common variants of uterine sarcoma are endometrial stromal sarcoma, leiomyosarcoma and carcinosarcoma. Based on relatively small case series, the literature provides little information on the risk factors, the n...

Uterine carcinosarcoma: A review of the literature.

OBJECTIVE Uterine carcinosarcomas (UCSs) are aggressive tumors previously considered to be sarcomas, but now recognized as malignancies composed of metaplastic transformation of epithelial elements. Much of the management for UCS has been extrapolated from studies of endometrial carcinomas and sarcomas. This article critically reviews the literature pertinent to the pathology, pathogenesis, dia...

The uterine carcinosarcoma - a case report.

The carcinosarcoma is a malignant mixed müllerian tumor with a highly malignant, biphasic tumor consisting of both epithelial and mesenchymal components. The presented case refers to a patient in climax with a vaginal bleeding. The Doppler echography highlights a polypoid mass, which prolapses in the cervical channel. The histopathological and immunohistochemical analysis of the surgically rese...

Uterine carcinosarcoma, leiomyosarcoma and endometrial stromal sarcoma : Epidemiological, clinical and prognostic aspects